Stilwill E W, Sahgal V
Arch Phys Med Rehabil. 1977 May;58(5):201-6.
The effects of upper and lower motor neuron lesions on human skeletal muscles and muscle spindles were studied using histochemical and morphometric techniques. In the lower motor neuron lesions, the muscle fibers showed group atrophy, fiber type grouping and target fibers. The muscle spindle demonstrated thickening of the capsule, degeneration of the nuclear chain fibers, targeting and splitting of the bag fibers. In the upper motor neuron lesion, the muscles showed group atrophy with histochemical evidence of preferential type II fiber involvement. Histometrics, however, failed to demonstrate type II fiber atrophy but showed hypertrophy of type I fibers. The muscle spindles only showed increased number of intrafusal fibers.
运用组织化学和形态测量技术研究了上运动神经元和下运动神经元损伤对人体骨骼肌和肌梭的影响。在下运动神经元损伤中，肌纤维呈现成群萎缩、纤维类型分组和靶纤维现象。肌梭表现为被膜增厚、核链纤维变性、袋状纤维靶向和分裂。在上运动神经元损伤中，肌肉出现成群萎缩，组织化学证据显示Ⅱ型纤维优先受累。然而，组织测量学未能证实Ⅱ型纤维萎缩，但显示Ⅰ型纤维肥大。肌梭仅表现为梭内纤维数量增加。
