Gloor E, Hurlimann J
Am J Clin Pathol. 1984 Jan;81(1):105-9. doi: 10.1093/ajcp/81.1.105.
A 43-year-old para 3 woman presented with a six-year history of progressive oligomenorrhea and hypomenorrhea. A total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed for the suspicion of ovarian cysts. On histologic examination, the ovaries contained lymphocytic and plasma cell infiltrates in relation to the theca interna of growing follicles, to the corpora lutea and to the endocrine hilar cells. The infiltrates increased in density with the follicular maturation and culminated against the corpora lutea. The plasma cell population was polyclonal. No antibodies to ovarian tissue components could be demonstrated in the patient's serum by means of immunohistochemistry; but antibodies to the zona glomerulosa of adrenal cortex were detected by serologic means. Although a rare disease, autoimmune oophoritis must be recognized histologically because it is a cause of ovarian failure and because it indicates that the patient is at risk of developing associated Addison's disease.
一名43岁、孕3产的女性，有6年进行性月经过少和稀发月经病史。因怀疑卵巢囊肿行全腹子宫切除术及双侧输卵管卵巢切除术。组织学检查发现，卵巢内生长卵泡的卵泡内膜、黄体及内分泌性门细胞有淋巴细胞和浆细胞浸润。随着卵泡成熟，浸润密度增加，并在黄体处达到高峰。浆细胞群体为多克隆性。通过免疫组织化学方法在患者血清中未检测到针对卵巢组织成分的抗体；但通过血清学方法检测到针对肾上腺皮质球状带的抗体。自身免疫性卵巢炎虽然是一种罕见疾病，但必须通过组织学予以识别，因为它是卵巢功能衰竭的一个原因，并且表明患者有发生相关Addison病的风险。
