Nishino T, Shirahata M, Yonezawa T, Honda Y
Anesthesiology. 1984 Jan;60(1):19-24. doi: 10.1097/00000542-198401000-00005.
The effects of increasing depths of anesthesia on the activities of the hypoglossal nerve (HN) and the phrenic nerve (PN) were investigated in artificially ventilated, vagotomized cats. An abrupt increase in inspired concentration of halothane from 1% to 4% immediately decreased both HN and PN activities, but HN activity decreased more and disappeared much earlier than did PN activity. Steady-state responses of HN and PN activities to changes in end-tidal concentration of halothane showed that halothane depressed both HN and PN activities in a dose-related manner but at different rates, suggesting that respiratory control of the tongue muscles and the diaphragm are in part mediated by different neural pathways. Differential suppression of PN and HN activities also was observed following an acute increase in anesthetic depth with thiopental and diazepam. In contrast, no such differential suppression was observed following ketamine administration. Thus, differential suppression of PN and HN may be associated not only with depth of anesthesia but also with the type of anesthetic used.
在人工通气、迷走神经切断的猫身上，研究了麻醉深度增加对舌下神经（HN）和膈神经（PN）活动的影响。吸入氟烷浓度从1%突然增加到4%，立即降低了HN和PN的活动，但HN活动下降得更多，且比PN活动更早消失。HN和PN活动对呼气末氟烷浓度变化的稳态反应表明，氟烷以剂量相关的方式抑制HN和PN活动，但速率不同，这表明舌肌和膈肌的呼吸控制部分由不同的神经通路介导。在硫喷妥钠和地西泮使麻醉深度急性增加后，也观察到了PN和HN活动的差异抑制。相比之下，给予氯胺酮后未观察到这种差异抑制。因此，PN和HN的差异抑制可能不仅与麻醉深度有关，还与所用麻醉剂的类型有关。
