Allen-Mersh T G
Ann R Coll Surg Engl. 1984 Jan;66(1):14-6.
Serum CEA was measured at 6-monthly intervals, over a 3-year period, in 102 patients being followed up after apparently complete excision of colorectal carcinoma. Residual disease was identified in 27 patients and was preceded by a CEA rise in 22 of these patients (81.5%). The CEA was initially normal in 68% of patients with residual disease in whom it subsequently rose. Rise in CEA was not detected until a median of 14 weeks before recurrence was diagnosed clinically. CEA-instigated second-look laparotomy was performed in 7 patients (31.5% of cases with CEA-associated residual disease). Despite a high resectability rate, no patient was cured. The results might have been improved by more frequent CEA measurement and more immediate second-look laparotomy, but in this study, CEA rise was not associated with surgically curable residual disease.
在3年期间，对102例结直肠癌明显完全切除术后接受随访的患者，每隔6个月检测一次血清癌胚抗原（CEA）。27例患者被发现有残留病灶，其中22例（81.5%）在残留病灶出现之前CEA就已升高。在残留病灶患者中，68%的患者CEA最初正常，随后才升高。直到临床诊断复发前中位数14周时才检测到CEA升高。7例患者（CEA相关残留病灶病例的31.5%）接受了CEA引发的二次剖腹探查术。尽管切除率很高，但没有患者治愈。通过更频繁地检测CEA和更及时地进行二次剖腹探查术，结果可能会有所改善，但在本研究中，CEA升高与手术可治愈的残留病灶无关。
