Kumagai Y, Shiokawa Y, Medsger T A, Rodnan G P
Arthritis Rheum. 1984 Jan;27(1):1-12. doi: 10.1002/art.1780270101.
Connective tissue disease has been reported to occur following cosmetic surgery with injection of the foreign substances paraffin and silicone (human adjuvant disease). The clinical findings in 18 such patients and a review of 28 additional cases from the Japanese literature are presented. The patients were classified into 2 major groups: group I consisted of 24 patients with definite connective tissue disease--12 with scleroderma, including 8 with progressive systemic sclerosis (PSS), 6 with rheumatoid arthritis, 5 with systemic lupus erythematosus, and 1 with polymyositis; group II consisted of 22 patients with human adjuvant disease with some symptoms, signs, and laboratory abnormalities suggestive, but not diagnostic of a connective tissue disease. The occurrence of PSS is approximately three-fold greater than expected for all women believed to have undergone such surgery, and PSS developed primarily in individuals injected with paraffin. Prolonged exposure to the injected substance may play a role in the induction of these immunologic disorders.
据报道，在注射石蜡和硅酮等外来物质的整容手术后会发生结缔组织病（人类佐剂病）。本文介绍了18例此类患者的临床发现，并对日本文献中的另外28例病例进行了回顾。患者分为两大组：第一组由24例确诊为结缔组织病的患者组成——12例患有硬皮病，其中8例患有进行性系统性硬化症（PSS），6例患有类风湿性关节炎，5例患有系统性红斑狼疮，1例患有多发性肌炎；第二组由22例患有人类佐剂病的患者组成，这些患者有一些症状、体征和实验室异常，提示但不能诊断为结缔组织病。PSS的发生率比所有被认为接受过此类手术的女性预期的发生率高出约三倍，且PSS主要发生在注射石蜡的个体中。长期接触注射物质可能在这些免疫紊乱的诱发中起作用。
