Kumagai Y, Abe C, Shiokawa Y
Arthritis Rheum. 1979 May;22(5):532-7. doi: 10.1002/art.1780220514.
In 9 cases of human adjuvant disease, 4 cases of scleroderma (3 progressive systemic sclerosis and 1 localized morphea) were observed. Seven to 19 years after injection of foreign substances into the breasts or nose for cosmetic purposes, some patients developed human adjuvant disease. In one case the foreign substances were removed by bilateral mastectomy with no discernible effects on the patient's clinical course. Histopathologic findings of the removed breasts demonstrated foreign body granulomas with calcification. The injected substance was identified as a mixture of liquid and solid paraffin. Human adjuvant disease might be caused by prolonged hypersensitization activated by the injected foreign materials which act as an adjuvant.
在9例人类佐剂病患者中，观察到4例硬皮病（3例进行性系统性硬化症和1例局限性硬斑病）。在为美容目的将异物注射到乳房或鼻子7至19年后，一些患者患上了人类佐剂病。在1例病例中，通过双侧乳房切除术取出了异物，但对患者的临床病程没有明显影响。切除乳房的组织病理学检查结果显示有钙化的异物肉芽肿。注射的物质被鉴定为液体和固体石蜡的混合物。人类佐剂病可能是由注射的作为佐剂的异物激活的长期超敏反应引起的。
