非甾体抗炎药三水杨酸胆碱镁对胃黏膜细胞脱落的影响。
The effect of the non-steroidal anti-inflammatory drug choline magnesium trisalicylate on gastric mucosal cell exfoliation.
作者信息
Mitchell K G, Hearns J, Crean G P
出版信息
Br J Clin Pharmacol. 1984 Jan;17(1):27-30. doi: 10.1111/j.1365-2125.1984.tb04994.x.
Abstract
Gastric mucosal cell exfoliation was measured in 10 normal subjects taking choline magnesium trisalicylate (CMT), aspirin and placebo. Both drugs resulted in significantly elevated rates of exfoliation although the serum salicylate levels achieved with aspirin were lower than those achieved by CMT. Side-effects of tinnitus, nausea and increased faecal blood loss were more common while subjects were taking CMT.
摘要
对10名服用胆碱镁三水杨酸酯（CMT）、阿司匹林和安慰剂的正常受试者进行了胃黏膜细胞脱落情况的测量。两种药物均导致脱落率显著升高，尽管阿司匹林所达到的血清水杨酸水平低于CMT所达到的水平。在受试者服用CMT时，耳鸣、恶心和粪便失血增加等副作用更为常见。
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