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1
Plasma lipid fractions during long-term monotherapy with the ISA-containing beta-adrenoceptor blocker bopindolol in hypertensive patients.高血压患者长期使用含内源性拟交感活性的β-肾上腺素能受体阻滞剂波吲洛尔单药治疗期间的血浆脂质组分
Br J Clin Pharmacol. 1984 Jan;17(1):86-8. doi: 10.1111/j.1365-2125.1984.tb05004.x.
2
Plasma lipid fractions during bopindolol treatment in hypertensive patients.
J Cardiovasc Pharmacol. 1986;8 Suppl 6:S42-4. doi: 10.1097/00005344-198608006-00010.
3
Effects of chronic oral administration of a new beta-blocker, bopindolol, on serum lipoprotein concentrations and blood pressure of spontaneously hypertensive rats.
Arch Int Pharmacodyn Ther. 1989 Nov-Dec;302:145-57.
4
Effects of a new long-acting beta-blocker bopindolol (LT 31-200) on blood pressure, plasma catecholamines, renin and cholesterol in patients with arterial hypertension.新型长效β受体阻滞剂波吲洛尔（LT 31 - 200）对动脉高血压患者血压、血浆儿茶酚胺、肾素及胆固醇的影响
Eur J Clin Pharmacol. 1982;22(6):491-3. doi: 10.1007/BF00609620.
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Acute and long-term antihypertensive effect of bopindolol--a nonselective beta-adrenergic blocker with ISA.波吲洛尔（一种具有内在拟交感活性的非选择性β肾上腺素能阻滞剂）的急性和长期降压作用
Eur J Clin Pharmacol. 1985;29(3):281-5. doi: 10.1007/BF00544081.
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Antihypertensive treatment with bopindolol alone or combined with a diuretic in general practice.
J Cardiovasc Pharmacol. 1986;8 Suppl 6:S80-7. doi: 10.1097/00005344-198608006-00019.
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[The antihypertensive efficacy and tolerance of bopindolol (LT 31-200) in hypertensive patients].
Rev Med Univ Navarra. 1990 Apr-Jun;34(2):90-4.
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Dose-finding study with bopindolol in arterial hypertension.
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Antihypertensive efficacy of the new long-acting beta-blocker bopindolol as related to age.
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Bopindolol, a new long-acting beta-adrenoceptor antagonist--a randomized comparison against propranolol in hypertensive patients.波吲洛尔，一种新型长效β肾上腺素能受体拮抗剂——与普萘洛尔治疗高血压患者的随机对照研究
Int J Clin Pharmacol Res. 1983;3(2):89-93.

引用本文的文献

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Haemodynamic effects of short-term treatment with bopindolol in essential hypertension.
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Bopindolol. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy.波吲洛尔：其药效学、药代动力学特性及治疗效果综述
Drugs. 1991 Jan;41(1):130-49. doi: 10.2165/00003495-199141010-00010.

本文引用的文献

1
Antihypertensive efficacy of the new long-acting beta-blocker bopindolol as related to age.
J Cardiovasc Pharmacol. 1983 May-Jun;5(3):426-9. doi: 10.1097/00005344-198305000-00012.
2
The relevance of intrinsic sympathomimetic activity for beta-blocker-induced changes in plasma lipids.
J Cardiovasc Pharmacol. 1983;5 Suppl 1:S51-5. doi: 10.1097/00005344-198300051-00008.
3
The emerging problem of plasma lipid changes during antihypertensive therapy.抗高血压治疗期间血浆脂质变化这一新兴问题。
J Cardiovasc Pharmacol. 1982;4 Suppl 2:S213-21.
4
Effects of a new long-acting beta-blocker bopindolol (LT 31-200) on blood pressure, plasma catecholamines, renin and cholesterol in patients with arterial hypertension.新型长效β受体阻滞剂波吲洛尔（LT 31 - 200）对动脉高血压患者血压、血浆儿茶酚胺、肾素及胆固醇的影响
Eur J Clin Pharmacol. 1982;22(6):491-3. doi: 10.1007/BF00609620.
5
beta-blockers or diuretics in hypertension? A six year follow-up of blood pressure and metabolic side effects.高血压治疗中使用β受体阻滞剂还是利尿剂？血压及代谢副作用的六年随访
Lancet. 1981 Apr 4;1(8223):744-7. doi: 10.1016/s0140-6736(81)92624-6.
6
Effect of propranolol and prazosin on blood lipids. The Oslo Study.普萘洛尔和哌唑嗪对血脂的影响。奥斯陆研究。
Lancet. 1980 Jul 5;2(8184):4-6. doi: 10.1016/s0140-6736(80)92888-3.
7
Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions.通过用聚阴离子沉淀从人血清中分离脂蛋白的快速方法。
J Lipid Res. 1970 Nov;11(6):583-95.

高血压患者长期使用含内源性拟交感活性的β-肾上腺素能受体阻滞剂波吲洛尔单药治疗期间的血浆脂质组分

Plasma lipid fractions during long-term monotherapy with the ISA-containing beta-adrenoceptor blocker bopindolol in hypertensive patients.

作者信息

Van Brummelen P, Bolli P, Koolen M I, Staehelin H B, Bühler F R

出版信息

Br J Clin Pharmacol. 1984 Jan;17(1):86-8. doi: 10.1111/j.1365-2125.1984.tb05004.x.

DOI:10.1111/j.1365-2125.1984.tb05004.x
PMID:6691892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1463290/
Abstract

The influence of bopindolol monotherapy on blood pressure and plasma lipid fractions was investigated in 24 hypertensive patients. Bopindolol lowered blood pressure and heart rate significantly. When compared with placebo no changes were found in the plasma concentrations of total cholesterol, LDL cholesterol and HDL cholesterol. Plasma triglycerides were significantly increased after 4 and 8 weeks but not after 12 weeks of bopindolol. It is concluded that bopindolol is an effective and well tolerated beta-adrenoceptor blocker in hypertensive patients. The fact that it does not lower HDL cholesterol could be a potential advantage.

摘要

在24例高血压患者中研究了波吲洛尔单一疗法对血压和血浆脂质成分的影响。波吲洛尔能显著降低血压和心率。与安慰剂相比，总胆固醇、低密度脂蛋白胆固醇和高密度脂蛋白胆固醇的血浆浓度未发现变化。服用波吲洛尔4周和8周后血浆甘油三酯显著升高，但12周后未升高。结论是波吲洛尔在高血压患者中是一种有效且耐受性良好的β-肾上腺素能受体阻滞剂。它不降低高密度脂蛋白胆固醇这一事实可能是一个潜在优势。