Harron D W, Goa K L, Langtry H D
Queen's University, Belfast, Northern Ireland.
Drugs. 1991 Jan;41(1):130-49. doi: 10.2165/00003495-199141010-00010.
Bopindolol is a nonselective beta-adrenoceptor antagonist [corrected] with partial agonist activity which is used in the treatment of hypertension. The drug is rapidly metabolised to an active hydrolysed form. The antihypertensive effects of bopindolol 0.5 to 4 mg are sustained for more than 24 hours after once daily dosing, and the drug appears similar in efficacy to propranolol, metoprolol, atenolol, pindolol and slow release nifedipine in the treatment of mild to moderate forms of this disease. In limited trials bopindolol has also successfully reduced symptoms in patients with angina pectoris, anxiety and essential tremor. Thus, bopindolol is an effective and well-tolerated beta-adrenoceptor antagonist.
波吲洛尔是一种具有部分激动剂活性的非选择性β肾上腺素能受体拮抗剂，用于治疗高血压。该药物迅速代谢为活性水解形式。每日一次服用0.5至4毫克波吲洛尔后的降压作用可持续超过24小时，在治疗轻至中度高血压方面，该药物的疗效似乎与普萘洛尔、美托洛尔、阿替洛尔、吲哚洛尔和缓释硝苯地平相似。在有限的试验中，波吲洛尔还成功减轻了心绞痛、焦虑症和特发性震颤患者的症状。因此，波吲洛尔是一种有效且耐受性良好的β肾上腺素能受体拮抗剂。
