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职业性接触肼及后续癌症风险。

Occupational exposure to hydrazine and subsequent risk of cancer.

作者信息

Wald N, Boreham J, Doll R, Bonsall J

出版信息

Br J Ind Med. 1984 Feb;41(1):31-4. doi: 10.1136/oem.41.1.31.

Abstract

Four hundred and twenty seven men with varying degrees of occupational exposure to hydrazine, a weak animal carcinogen, were studied to see if they provided any evidence of carcinogenicity to man. The observed mortality was close to that expected for lung cancer, other cancers, and all other causes, irrespective of the level of exposure. There were 49 deaths (61.47 expected) from all causes including five deaths from lung cancer (6.65 expected). The results show that no obvious hazards associated with hydrazine exposure have yet appeared but because of the small number of men studied they can only exclude gross hazards.

摘要

对427名职业性接触不同程度肼(一种弱动物致癌物)的男性进行了研究,以确定其是否对人类具有致癌性。无论接触水平如何,观察到的死亡率与肺癌、其他癌症以及所有其他病因的预期死亡率相近。包括肺癌死亡5例(预期6.65例)在内,所有病因导致的死亡共49例(预期61.47例)。结果表明,尚未出现与肼接触相关的明显危害,但由于研究对象数量较少,只能排除严重危害。

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