职业性接触肼与后续癌症风险
Occupational exposure to hydrazine and subsequent risk of cancer.
作者信息
Morris J, Densem J W, Wald N J, Doll R
机构信息
Wolfson Institute of Preventive Medicine, St Bartholomew's Hospital Medical College, London.
出版信息
Occup Environ Med. 1995 Jan;52(1):43-5. doi: 10.1136/oem.52.1.43.
OBJECTIVES
The aim was to examine the cause specific mortality of men exposed to hydrazine.
METHODS
Hydrazine was produced at a factory in the east midlands between 1945 and 1971. The cohort of all 427 men who were employed there for at least six months with varying degrees of occupational exposure to hydrazine were followed up until the end of January 1992.
RESULTS
By the end of July 1982 49 deaths had occurred and the observed mortality was found to be close to that expected at each level of exposure. By the end of January 1992 a further 37 deaths had occurred. Again the observed mortality was close to that expected for all causes and also for lung cancer, cancers of the digestive system, other cancers, and all other causes, irrespective of the level of exposure.
CONCLUSIONS
The results weigh against there having been any material hazard of occupational exposure to hydrazine. The small number of men studied means, however, that a relative risk as high as 3.5 for lung cancer cannot confidently be excluded.
目的
旨在研究接触肼的男性的死因别死亡率。
方法
1945年至1971年间，英国西米德兰兹郡的一家工厂生产肼。对所有427名在该厂工作至少六个月、不同程度职业接触肼的男性进行队列随访，直至1992年1月底。
结果
到1982年7月底，已有49人死亡，各接触水平下的观察到的死亡率与预期死亡率接近。到1992年1月底，又有37人死亡。同样，无论接触水平如何，所有原因、肺癌、消化系统癌症、其他癌症以及所有其他原因的观察到的死亡率都与预期死亡率接近。
结论
结果表明职业接触肼不存在重大危害。然而，研究的男性数量较少，意味着不能排除肺癌相对风险高达3.5的可能性。
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