散发性单侧视网膜母细胞瘤患者的染色体脆性
Chromosome fragility in patients with sporadic unilateral retinoblastoma.
作者信息
de Nuñez M, Penchaszadeh V B, Pimentel E
出版信息
Cancer Genet Cytogenet. 1984 Feb;11(2):139-41. doi: 10.1016/0165-4608(84)90107-9.
PMID:6692335
Abstract
Banded karyotypes were prepared from short-term cultures of lymphocytes from the peripheral blood of ten patients with untreated sporadic unilateral retinoblastoma and ten matched controls. Different types of structural chromosome aberrations were observed in the patients, including a statistically significant increase of chromatid and isochromatid gaps and breaks.
摘要
对10例未经治疗的散发性单侧视网膜母细胞瘤患者及10例匹配对照者外周血淋巴细胞进行短期培养，制备显带核型。在患者中观察到不同类型的染色体结构畸变，包括染色单体和等染色单体间隙及断裂在统计学上显著增加。
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