Wang C Y, Croft W A, Bryan G T
Cancer Lett. 1984 Jan;21(3):303-8. doi: 10.1016/0304-3835(84)90009-0.
Weanling female germ-free Sprague-Dawley rats were divided into 3 groups: the control group rats were fed an autoclaved 5010C diet for 2 years; the nitrofurantoin (NF) group rats were fed this diet supplemented with 0.188% NF for 2 years; and the N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT) group rats were fed this diet supplemented with 0.188% FANFT for 20 weeks followed by 20 additional weeks of the control diet. The FANFT-group rats were killed following the early appearance of bladder tumors. Six of 11 control rats had tumors: 2 with mammary fibroadenomas, 1 with adrenal adenoma, 1 with leukemic spleen, and 2 with mesenchymal sarcoma of the colon. Ten of 12 NF-group rats had tumors: 9 with mammary fibroadenomas, 1 with adrenal adenoma, and 1 each with leukemic spleen and cervical squamous cell carcinoma. Eight of 12 FANFT-group rats had tumors: 7 with bladder and 1 with renal pelvis transitional cell carcinoma. The incidences of mammary fibroadenoma in the NF group and of lower urinary tract tumors in the FANFT group were significantly greater (P less than 0.01) than those of these tumors in the control group.
将断奶的雌性无菌斯普拉格-道利大鼠分为3组：对照组大鼠喂食经高压灭菌的5010C饮食2年；呋喃妥因（NF）组大鼠喂食添加了0.188% NF的这种饮食2年；N-[4-(5-硝基-2-呋喃基)-2-噻唑基]-甲酰胺（FANFT）组大鼠先喂食添加了0.188% FANFT的这种饮食20周，随后再喂食20周对照饮食。FANFT组大鼠在膀胱肿瘤早期出现后处死。11只对照大鼠中有6只发生肿瘤：2只患有乳腺纤维腺瘤，1只患有肾上腺腺瘤，1只患有白血病脾脏，2只患有结肠间叶肉瘤。12只NF组大鼠中有10只发生肿瘤：9只患有乳腺纤维腺瘤，1只患有肾上腺腺瘤，1只患有白血病脾脏，1只患有宫颈鳞状细胞癌。12只FANFT组大鼠中有8只发生肿瘤：7只患有膀胱肿瘤，1只患有肾盂移行细胞癌。NF组乳腺纤维腺瘤和FANFT组下尿路肿瘤的发生率显著高于（P<0.01）对照组中这些肿瘤的发生率。
