Astrup A, Bülow J, Christensen N J, Madsen J
Clin Sci (Lond). 1984 Feb;66(2):179-86. doi: 10.1042/cs0660179.
The warmest interscapular skin areas were located by thermography in six healthy subjects during ephedrine-induced thermogenesis. In these interscapular areas, and in lumbar control areas, the skin temperature, subcutaneous temperature and adipose tissue blood flow were measured before and during ephedrine-induced thermogenesis. The skin and subcutaneous temperatures increased in the interscapular area as well as in the lumbar area, by about 0.7-1.2 degrees C. The interscapular skin temperature remained about 1 degree C higher than the lumbar; the subcutaneous temperatures in the two areas were identical during the experiments. Although the interscapular subcutaneous adipose tissue blood flow increased about sixfold and the lumbar increased twofold, the absolute flows were higher in the lumbar area. The oxygen uptake increased to a maximum of 30% above control level. Plasma glucose and glycerol concentrations remained unchanged, and plasma non-esterified fatty acids, lactate and noradrenaline concentrations increased slightly but significantly. Biopsies taken from the hot interscapular areas did not contain brown adipose tissue. It is concluded that the high interscapular skin temperature may be due to a lower insulating fat thickness and that the increases in skin and subcutaneous temperatures during ephedrine-induced thermogenesis are caused by an increased blood flow. These observations weigh against the hypothesis that the interscapular temperature increase is due to functional, interscapular brown adipose tissue.
通过热成像法在6名健康受试者中确定了麻黄碱诱导产热期间肩胛间最温暖的皮肤区域。在这些肩胛间区域以及腰部对照区域，测量了麻黄碱诱导产热前后的皮肤温度、皮下温度和脂肪组织血流量。肩胛间区域和腰部区域的皮肤和皮下温度均升高，约升高0.7-1.2摄氏度。肩胛间皮肤温度比腰部约高1摄氏度；实验期间两个区域的皮下温度相同。尽管肩胛间皮下脂肪组织血流量增加了约6倍，腰部增加了2倍，但腰部区域的绝对血流量更高。摄氧量增加至比对照水平最高高30%。血浆葡萄糖和甘油浓度保持不变，血浆非酯化脂肪酸、乳酸和去甲肾上腺素浓度略有但显著增加。取自肩胛间热区的活检组织中不含褐色脂肪组织。得出的结论是，肩胛间皮肤温度高可能是由于隔热脂肪厚度较低，并且麻黄碱诱导产热期间皮肤和皮下温度的升高是由血流量增加引起的。这些观察结果与肩胛间温度升高是由于肩胛间功能性褐色脂肪组织这一假设相悖。
