Jonat W, Knapp W, Schumann B, Trapp H, Vanhecke C, Maass H
Dtsch Med Wochenschr. 1984 Jan 13;109(2):46-9. doi: 10.1055/s-2008-1069136.
High-dosage medroxyprogesterone (Farlutal, 1 g/d orally) was administered to 42 female patients with progressive disseminated carcinomas of the breast after conventional cytostatic and hormonal treatment had failed. Besides evaluation of success of treatment the pharmacokinetics of medroxyprogesterone were investigated. A remission rate of 37% (total and partial remissions) indicated that high-dosage oral treatment with gestagens can be used as "failure-regime" in patients at the end of conventional treatment. The plasma level of the gestagen approached values corresponding to high-dosage intramuscular application.
对42例经传统细胞抑制和激素治疗失败的晚期播散性乳腺癌女性患者给予高剂量甲羟孕酮（法禄达，口服1g/天）。除评估治疗效果外，还对甲羟孕酮的药代动力学进行了研究。缓解率为37%（完全缓解和部分缓解），表明在传统治疗末期，高剂量口服孕激素治疗可作为患者的“挽救方案”。孕激素的血浆水平接近高剂量肌肉注射时的相应值。
