Firusian N, Becher R
Strahlentherapie. 1981 Dec;157(12):808-12.
Thirty patients with histologically proven metastatic mammary carcinoma were treated, after exhaustion of hormonal and cytostatic therapeutic means, with high-dosed medroxyprogesterone acetate (MPA) during a ten-day induction phase with 1000 mg MPAi.m. per day and then with 600 mg oral MPA per day. In eleven patients a complete or partial remission was achieved. The median period of remission comprised ten months. A positive relationship was found between the response to high-dosed MPA therapy and the length of free intervals. Side effects were tolerable.
30例经组织学证实的转移性乳腺癌患者，在激素及细胞抑制治疗手段无效后，于10天诱导期内接受大剂量醋酸甲羟孕酮（MPA）治疗，诱导期每天肌肉注射1000mg MPA，随后每天口服600mg MPA。11例患者实现了完全或部分缓解。缓解期的中位数为10个月。发现对大剂量MPA治疗的反应与无瘤间期长度之间存在正相关关系。副作用可以耐受。
