Benignus V A, Muller K E, Graham J A, Barton C N
Environ Res. 1984 Feb;33(1):39-46. doi: 10.1016/0013-9351(84)90006-9.
The relationship of toluene concentration in blood and brain to the concentration of toluene in inspired air has not been explicitly studied. Sixty rats were exposed by inhalation to 50, 100, 500, or 1000 ppm toluene for 3 hr. Immediately following exposure, venous blood samples and whole brains were collected and assayed for toluene levels. For several empirical reasons, the natural logarithm (log) of toluene tissue levels were predicted in a linear model from log toluene levels in air. An additional 10 rats were exposed to 550 ppm toluene for 8 hr in order to verify that the 3-hr exposure was sufficient to produce near-asymptotic levels of toluene in blood and brain. Log brain toluene concentration was significantly higher than log blood concentration by an additive constant. The ratio of brain to blood toluene level was estimated as 1.56/1. Three- and eight-hour exposure results did not differ, thus indicating that these results would hold for toluene exposures of 3 hr or greater.
血液和大脑中甲苯浓度与吸入空气中甲苯浓度的关系尚未得到明确研究。将60只大鼠通过吸入暴露于50、100、500或1000 ppm的甲苯中3小时。暴露后立即采集静脉血样本和全脑，并检测甲苯水平。出于几个经验性原因，在一个线性模型中根据空气中甲苯水平预测甲苯组织水平的自然对数（log）。另外10只大鼠暴露于550 ppm的甲苯中8小时，以验证3小时的暴露足以使血液和大脑中的甲苯水平接近渐近水平。大脑甲苯浓度的对数比血液浓度的对数显著高一个加性常数。大脑与血液中甲苯水平的比率估计为1.56/1。3小时和8小时的暴露结果没有差异，因此表明这些结果适用于3小时或更长时间的甲苯暴露。
