Hironaka T, Ikari Y, Miyata Y, Morimoto S, Tsunoo A
Exp Neurol. 1984 Feb;83(2):392-402. doi: 10.1016/S0014-4886(84)90107-9.
The etiology of avian muscular dystrophy was examined by a cross-transplantation technique. Care was taken for the transplants to regenerate and develop under neural influence, by using the small extensor carpi radialis longus (ECRL) muscle. The ECRL muscles were exchanged between normal and dystrophic chicks 2 to 3 days ex ovo, and the muscle weight, number of muscle fibers, muscle fiber size, and contractile properties of the transplanted muscles were observed 60 to 65 days after operation when the tissue reconstitution was virtually complete. The results obtained for the physiologic, anatomic, and histologic parameters strongly suggested that there exists some failure in the host environment of the dystrophic chicken. The analyses of the histologic parameters suggested that a genetic disorder may also reside in the muscle tissue itself. The myotonic nature of the muscle membrane, however, probably does not contribute significantly to the abnormal behavior of dystrophic chickens. The importance of some neurogenic abnormalities in avian muscular dystrophy is discussed in relation to the results reported by other investigators.
采用交叉移植技术研究了禽类肌肉萎缩症的病因。通过使用桡侧腕长伸肌（ECRL），小心确保移植组织在神经影响下再生和发育。在雏鸡出壳后2至3天，在正常雏鸡和患肌肉萎缩症的雏鸡之间交换ECRL肌肉，当组织重构基本完成后，于术后60至65天观察移植肌肉的重量、肌纤维数量、肌纤维大小及收缩特性。生理、解剖和组织学参数的结果有力地表明，患肌肉萎缩症的鸡的宿主环境存在某些缺陷。组织学参数分析表明，遗传紊乱可能也存在于肌肉组织本身。然而，肌膜的强直性本质可能对患肌肉萎缩症鸡的异常行为贡献不大。结合其他研究者报告的结果，讨论了禽类肌肉萎缩症中某些神经源性异常的重要性。
