Ferrell F, Tsuetaki T
Exp Neurol. 1984 Feb;83(2):429-35. doi: 10.1016/S0014-4886(84)90111-0.
We examined regenerative capabilities of vallate papilla and taste buds in a human adult after complete surgical excision of the papilla and underlying glands and muscle. Although trenchlike invaginations were observed in the healed epithelium biopsied 18 months after papilla removal, no normal papilla, characterized by definite boundaries and circular trench, could be found. A few regenerated taste buds, totaling slightly more than 7% of the number counted in the excised papilla, were present on the top surface of the regenerated epithelium. They were longer and narrower than the original buds, but otherwise appeared normal and most had distinct taste pores. Our findings confirm earlier reports that vallate papillae fail to reform if surgical excision is complete, but that taste buds can develop and will regenerate in tongue epithelium of nonhuman species without the presence of the original papilla.
我们在一名成年人类患者中，对轮廓乳头及味蕾在乳头及其下方腺体和肌肉完全手术切除后的再生能力进行了研究。尽管在乳头切除18个月后活检的愈合上皮中观察到了沟状凹陷，但未发现具有明确边界和圆形沟的正常乳头。在再生上皮的顶面存在少数再生味蕾，总数略多于切除乳头中所计数味蕾数量的7%。它们比原始味蕾更长更窄，但在其他方面看起来正常，且大多数具有明显的味孔。我们的研究结果证实了早期的报告，即如果手术切除彻底，轮廓乳头无法重新形成，但在没有原始乳头的情况下，味蕾可以在非人类物种的舌上皮中发育并再生。
