下丘脑肥胖大鼠棕色脂肪组织中脂肪酸合成速率降低。

Decreased rate of fatty acid synthesis in brown adipose tissue of hypothalamic obese rats.

作者信息

Saito M, Shimazu T

出版信息

FEBS Lett. 1984 Jan 23;166(1):151-4. doi: 10.1016/0014-5793(84)80062-9.

Abstract

Obese rats with lesions of the ventromedial hypothalamus (VMH) exhibited a 3-fold increase in the wet weight of interscapular brown adipose tissue (IBAT), due to an increased triglyceride content, compared with lean controls. The rate of lipogenesis in IBAT was much higher than that in white adipose tissues in control rats, but decreased greatly in rats with VMH lesions and approximated the value in white adipose tissues. It was suggested that thermogenesis in BAT was impaired after VMH lesions by decreasing triglyceride turnover in BAT.

摘要

与瘦素对照组相比，腹内侧下丘脑（VMH）损伤的肥胖大鼠肩胛间棕色脂肪组织（IBAT）的湿重增加了两倍，这是由于甘油三酯含量增加所致。IBAT中的脂肪生成速率远高于对照大鼠白色脂肪组织中的脂肪生成速率，但在VMH损伤的大鼠中大幅下降，接近白色脂肪组织中的值。研究表明，VMH损伤后，棕色脂肪组织（BAT）中的产热功能因BAT中甘油三酯周转率降低而受损。