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1
Glucose utilization in vivo and insulin-sensitivity of rat brown adipose tissue in various physiological and pathological conditions.不同生理和病理条件下大鼠棕色脂肪组织的体内葡萄糖利用及胰岛素敏感性
Biochem J. 1986 Jan 1;233(1):249-52. doi: 10.1042/bj2330249.
2
Development of obesity in Zucker rats. Early insulin resistance in muscles but normal sensitivity in white adipose tissue.Zucker大鼠肥胖的发展。肌肉早期出现胰岛素抵抗，但白色脂肪组织敏感性正常。
Diabetes. 1987 May;36(5):626-31. doi: 10.2337/diab.36.5.626.
3
Increased insulin action in rats with mild insulin deficiency induced by neonatal streptozotocin.新生期链脲佐菌素诱导的轻度胰岛素缺乏大鼠中胰岛素作用增强。
Am J Physiol. 1991 Apr;260(4 Pt 1):E561-7. doi: 10.1152/ajpendo.1991.260.4.E561.
4
The effect of insulin and noradrenaline on the uptake of 2-[1-14C]deoxyglucose in vivo by brown adipose tissue and other glucose-utilising tissues of the mouse.胰岛素和去甲肾上腺素对小鼠棕色脂肪组织及其他葡萄糖利用组织在体内摄取2-[1-¹⁴C]脱氧葡萄糖的影响。
FEBS Lett. 1985 Sep 2;188(2):257-61. doi: 10.1016/0014-5793(85)80383-5.
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Effects of intravenously infused leptin on insulin sensitivity and on the expression of uncoupling proteins in brown adipose tissue.静脉输注瘦素对胰岛素敏感性及棕色脂肪组织解偶联蛋白表达的影响。
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Vanadate treatment markedly increases glucose utilization in muscle of insulin-resistant fa/fa rats without modifying glucose transporter expression.钒酸盐治疗可显著提高胰岛素抵抗的fa/fa大鼠肌肉中的葡萄糖利用率，而不改变葡萄糖转运蛋白的表达。
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7
A method to quantify glucose utilization in vivo in skeletal muscle and white adipose tissue of the anaesthetized rat.一种在麻醉大鼠的骨骼肌和白色脂肪组织中定量体内葡萄糖利用的方法。
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8
Quantification in vivo of the effects of insulin on glucose utilization in individual tissues of warm- and cold-acclimated rats.体内定量研究胰岛素对暖适应和冷适应大鼠各组织葡萄糖利用的影响。
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9
Hyperinsulinemia and its impact on obesity and insulin resistance.高胰岛素血症及其对肥胖和胰岛素抵抗的影响。
Int J Obes Relat Metab Disord. 1992 Dec;16 Suppl 4:S1-11.
10
The effects of 2-deoxy-D-glucose on brown adipose tissue of lean and obese Zucker rats.2-脱氧-D-葡萄糖对瘦型和肥胖型 Zucker 大鼠棕色脂肪组织的影响。
Int J Obes. 1986;10(2):147-58.

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Protein O-GlcNAcylation levels are regulated independently of dietary intake in a tissue and time-specific manner during rat postnatal development.在大鼠出生后的发育过程中，蛋白质 O-GlcNAcylation 水平受到组织和时间特异性的调节，而不受饮食摄入的影响。
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Whitening and Impaired Glucose Utilization of Brown Adipose Tissue in a Rat Model of Type 2 Diabetes Mellitus.2 型糖尿病大鼠模型中棕色脂肪组织的白化和葡萄糖利用受损。
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Diet-induced obesity causes insulin resistance in mouse brown adipose tissue.饮食诱导的肥胖会导致小鼠棕色脂肪组织出现胰岛素抵抗。
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Effects of moderate global maternal nutrient reduction on fetal baboon renal mitochondrial gene expression at 0.9 gestation.孕期0.9时母体适度整体营养减少对胎狒狒肾线粒体基因表达的影响。
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本文引用的文献

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Factors influencing the acute effect of food on oxygen consumption in the rat.影响食物对大鼠耗氧量急性效应的因素。
Int J Obes. 1982;6(1):53-9.
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Alterations of brown adipose tissue in genetically obese (ob/ob) mice. I. Demonstration of loss of metabolic response to nerve stimulation and catecholamines and its partial recovery after fasting or cold adaptation.
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Brown-adipose-tissue lipogenesis in starvation: effects of insulin and (-) hydroxycitrate.饥饿状态下棕色脂肪组织的脂肪生成：胰岛素和（-）羟基柠檬酸的作用
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Increased lipogenesis in brown adipose tissue of lactating rats fed a cafeteria diet. The possible involvement of insulin in brown adipose tissue hypertrophy.喂食自助餐饮食的哺乳期大鼠棕色脂肪组织中脂肪生成增加。胰岛素可能参与棕色脂肪组织肥大。
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5
Lipogenesis in interscapular brown adipose tissue of virgin, pregnant and lactating rats. The effects of intragastric feeding.处女、怀孕和哺乳期大鼠肩胛间棕色脂肪组织中的脂肪生成。胃内喂养的影响。
Biochem J. 1980 Aug 15;190(2):477-80. doi: 10.1042/bj1900477.
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Effect of age and gene dosage on brown adipose tissue of Zucker obese fa/fa rats.年龄和基因剂量对Zucker肥胖fa/fa大鼠棕色脂肪组织的影响。
Am J Physiol. 1984 May;246(5 Pt 1):E391-6. doi: 10.1152/ajpendo.1984.246.5.E391.
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Decreased rate of fatty acid synthesis in brown adipose tissue of hypothalamic obese rats.下丘脑肥胖大鼠棕色脂肪组织中脂肪酸合成速率降低。
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Brown adipose tissue metabolism in lactating rats: the effect of litter size.哺乳期大鼠的棕色脂肪组织代谢：窝仔数的影响。
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Brown adipose tissue of mice with gold thioglucose-induced obesity: effect of cold and diet.
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Brown adipose tissue thermogenesis, energy balance, and obesity.棕色脂肪组织产热、能量平衡与肥胖
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不同生理和病理条件下大鼠棕色脂肪组织的体内葡萄糖利用及胰岛素敏感性

Glucose utilization in vivo and insulin-sensitivity of rat brown adipose tissue in various physiological and pathological conditions.

作者信息

Ferré P, Burnol A F, Leturque A, Terretaz J, Penicaud L, Jeanrenaud B, Girard J

出版信息

Biochem J. 1986 Jan 1;233(1):249-52. doi: 10.1042/bj2330249.

DOI:10.1042/bj2330249
PMID:3513758
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1153011/
Abstract

Brown-adipose-tissue glucose utilization rate and its insulin-sensitivity were measured in vivo in the anaesthetized rat by a 2-deoxy[1-3H]glucose technique. Glucose utilization can be increased 60-fold by insulin, to reach extremely high rates. Glucose utilization and its insulin-sensitivity are modulated in accordance with physiological or pathological conditions.

摘要

采用2-脱氧[1-³H]葡萄糖技术，在麻醉大鼠体内测量棕色脂肪组织的葡萄糖利用率及其胰岛素敏感性。胰岛素可使葡萄糖利用率提高60倍，达到极高水平。葡萄糖利用率及其胰岛素敏感性会根据生理或病理状况进行调节。