Smith D A, Burgdorf W H
J Am Acad Dermatol. 1984 Jan;10(1):106-9. doi: 10.1016/s0190-9622(84)80052-3.
A 10-year-old black girl with a severe hypersensitivity reaction to phenytoin is described. Adverse effects included interstitial nephritis, hepatitis, and toxic epidermal necrolysis. An apparently permanent sequela of universal cutaneous depigmentation developed. Although the presence of clear cells in the basal layer of the epidermis suggested that melanocytes might still be present, these clear cells were shown, by electron microscopy, to be Langerhans cells and not melanocytes. This patient demonstrates a unique outcome, not previously described in the literature.
本文描述了一名对苯妥英钠有严重过敏反应的10岁黑人女孩。不良反应包括间质性肾炎、肝炎和中毒性表皮坏死松解症。出现了明显的全身性皮肤色素脱失这一永久性后遗症。尽管表皮基底层中透明细胞的存在提示黑素细胞可能仍然存在，但通过电子显微镜显示这些透明细胞是朗格汉斯细胞而非黑素细胞。该患者表现出一种文献中未曾描述过的独特结局。
