Matzner Y, Brzezinski A
J Lab Clin Med. 1984 Feb;103(2):227-35.
Peritoneal fluid was found to contain an inhibitor of neutrophil chemotaxis. The inhibitor was effective only against the chemotactic activity of zymosan-activated serum (including purified C5a) and had no effect when f-met-leu-phe served as chemoattractant. Inhibition was not the result of a direct effect on the neutrophils, since incubation of cells with the peritoneal fluid did not alter their chemotactic response. The inhibitor was found to be a protein with a molecular weight of approximately 40,000 dalton by gel filtration. It resembles the inhibitor previously described by us in synovial fluids, and thus it is proposed to play a role in the regulation of inflammation in serosal tissues.
发现腹腔液中含有一种中性粒细胞趋化作用抑制剂。该抑制剂仅对酵母聚糖激活的血清（包括纯化的C5a）的趋化活性有效，而当f-甲硫-亮-苯丙氨酸作为趋化剂时则无效。抑制作用并非对中性粒细胞直接作用的结果，因为将细胞与腹腔液一起孵育并未改变其趋化反应。通过凝胶过滤发现该抑制剂是一种分子量约为40,000道尔顿的蛋白质。它类似于我们之前在滑液中描述的抑制剂，因此推测它在浆膜组织炎症调节中发挥作用。
