人蛋白HC及其IgA复合物是中性粒细胞趋化作用的抑制剂。
Human protein HC and its IgA complex are inhibitors of neutrophil chemotaxis.
作者信息
Méndez E, Fernández-Luna J L, Grubb A, Leyva-Cobián F
出版信息
Proc Natl Acad Sci U S A. 1986 Mar;83(5):1472-5. doi: 10.1073/pnas.83.5.1472.
Protein HC, a heterogeneously charged low molecular weight glycoprotein, and its IgA complex were isolated from human plasma and urine. Plasma from individuals with monoclonal IgA populations was used as starting material for the isolation of the protein HC-IgA complex to obtain homogeneous complex populations. Neither low molecular weight protein HC nor its IgA complex in the concentrations 30 and 600 mg/liter influenced the random migration of normal human neutrophils. The chemotactic response of neutrophils to endotoxin-activated serum was, however, attenuated in a dose-dependent way by both low molecular weight protein HC and protein HC-IgA complex. Concentrations of protein HC and its IgA complex producing significant inhibition of the chemotactic response were found to occur in plasma from healthy and diseased individuals as well as in synovial fluid from patients with rheumatoid arthritis. These results suggest that protein HC and its IgA complex play physiological roles in the regulation of the inflammatory response.
蛋白质HC是一种带异电荷的低分子量糖蛋白，其IgA复合物从人血浆和尿液中分离得到。来自具有单克隆IgA群体个体的血浆用作分离蛋白质HC-IgA复合物的起始材料，以获得均一的复合物群体。浓度为30和600毫克/升的低分子量蛋白质HC及其IgA复合物均不影响正常人中性粒细胞的随机迁移。然而，低分子量蛋白质HC和蛋白质HC-IgA复合物均以剂量依赖的方式减弱了中性粒细胞对内毒素激活血清的趋化反应。发现蛋白质HC及其IgA复合物产生显著趋化反应抑制作用的浓度存在于健康人和患病个体的血浆以及类风湿性关节炎患者的滑液中。这些结果表明，蛋白质HC及其IgA复合物在炎症反应调节中发挥生理作用。
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