Collett J H, Flood B L
J Pharm Pharmacol. 1976 Mar;28(3):206-9. doi: 10.1111/j.2042-7158.1976.tb04132.x.
Solubilities and dissolution rates of salicylic acid have been determined in urea solutions at different pH values. Solubilities increased with pH and urea concentration; a solubilization mechanism was considered to be operating. The solubilization effect of urea was greatest on the non-ionzed moieties of the solute. Dissolution rates of salicylic acid increased with pH and urea concentration. The increase in dissolution rate paralleled increases in solubility. The role of solubilizing effect in the enhancement of dissolution rate by urea is discussed.
已测定水杨酸在不同pH值的尿素溶液中的溶解度和溶解速率。溶解度随pH值和尿素浓度的增加而增加；认为存在一种增溶机制。尿素对溶质的非离子化部分增溶作用最大。水杨酸的溶解速率随pH值和尿素浓度的增加而增加。溶解速率的增加与溶解度的增加平行。讨论了增溶作用在尿素提高溶解速率中的作用。
