Giacoia G P, Gessner P K, Zaleska M M, Boutwell W C
J Pediatr. 1984 Feb;104(2):291-6. doi: 10.1016/s0022-3476(84)81017-3.
The pharmacokinetic parameters controlling paraldehyde elimination were determined in nine infants infused with paraldehyde at the rate of 150 mg/kg/hr in a 5% solution in 5% dextrose for the treatment of status epilepticus. The mean +/- SEM values for the observed parameters were as follows: rate constant for the disposition of paraldehyde 0.0680 +/- 0.0071 hr,-1 half-life 10.2 +/- 1.0 hr; volume of distribution 1.73 +/- 0.20 L/kg; clearance 0.121 +/- 0.023 L/hr/kg. Phenobarbital administration prior to or within 24 hours of the cessation of paraldehyde infusion decreased both paraldehyde clearance and volume of distribution in a manner linearly related to the logarithm of the phenobarbital dose. The rate constant for paraldehyde elimination was decreased as a linear function of the logarithm of the combined dose of administered phenobarbital and phenytoin. No acetaldehyde was detected in any blood samples. Paraldehyde administration was not correlated with any adverse reactions or toxicities.
在9名因治疗癫痫持续状态而以150mg/kg/小时的速率输注聚乙醛（以5%葡萄糖中的5%溶液形式）的婴儿中，测定了控制聚乙醛消除的药代动力学参数。观察参数的均值±标准误如下：聚乙醛处置的速率常数为0.0680±0.0071小时⁻¹，半衰期为10.2±1.0小时；分布容积为1.73±0.20L/kg；清除率为0.121±0.023L/小时/kg。在聚乙醛输注停止前或停止后24小时内给予苯巴比妥，会使聚乙醛清除率和分布容积均降低，其降低方式与苯巴比妥剂量的对数呈线性相关。聚乙醛消除的速率常数作为所给予苯巴比妥和苯妥英联合剂量对数的线性函数而降低。在任何血样中均未检测到乙醛。给予聚乙醛与任何不良反应或毒性均无相关性。
