Curless R G, Holzman B H, Ramsay R E
Arch Neurol. 1983 Aug;40(8):477-80. doi: 10.1001/archneur.1983.04210070017006.
Intravenous (IV) diazepam or phenobarbital is generally accepted as the initial treatment of choice for status epilepticus in children. The risk of severe respiratory depression with either drug is a major problem, particularly in emergency centers that do not have appropriate equipment or personnel for rapid endotracheal intubation of infants. While some pediatric centers are not reluctant to recommend paraldehyde for secondary therapy in status epilepticus, most texts and publications recommend it only as a last resort because of reported complications. We investigated the benefits and complications from varied dosing regimens in 16 trials. The results indicated no significant complications in patients who did not receive an initial IV bolus. Even though treatment with phenobarbital or diazepam and phenytoin sodium had failed, 37% had a good therapeutic response.
静脉注射地西泮或苯巴比妥通常被认为是儿童癫痫持续状态的首选初始治疗方法。这两种药物引发严重呼吸抑制的风险是一个主要问题，特别是在那些没有合适设备或人员对婴儿进行快速气管插管的急救中心。虽然一些儿科中心不反对推荐副醛用于癫痫持续状态的二线治疗，但由于有报道称其存在并发症，大多数文献和出版物仅将其作为最后手段推荐。我们在16项试验中研究了不同给药方案的益处和并发症。结果表明，未接受初始静脉推注的患者没有明显并发症。即使苯巴比妥、地西泮或苯妥英钠治疗失败，仍有37%的患者有良好的治疗反应。
