Berner B, Cooper E R
J Pharm Sci. 1984 Jan;73(1):102-6. doi: 10.1002/jps.2600730127.
A diffusion model for transport through multilaminates is studied as a possible way to predict the optimal biological response of a set of congeners with respect to the oil-water partition coefficient, P. The model predicts the bilinear form typical of biological response data and, unlike the earlier kinetic model, also relates the results to physical processes, predicts the structure with the optimal response in terms of diffusion constants, and shows such an optimum prior to steady state for an infinite dose. Diffusion through an oil-water multilaminate causes extraordinary separation of permeating species based on partition coefficient and diffusion constant for times shorter than the lag time.
研究了一种用于预测多层结构中传输的扩散模型，作为预测一组同系物相对于油水分配系数P的最佳生物学响应的一种可能方法。该模型预测了生物学响应数据典型的双线性形式，并且与早期的动力学模型不同，它还将结果与物理过程相关联，根据扩散常数预测具有最佳响应的结构，并显示在无限剂量的稳态之前就存在这样的最优值。在短于滞后时间的时间段内，通过油水多层结构的扩散会基于分配系数和扩散常数对渗透物种进行非凡的分离。
