Ruenwongsa P, Pattanavibag S
Life Sci. 1984 Jan 23;34(4):365-70. doi: 10.1016/0024-3205(84)90625-8.
The synthesis of whole brain acetylcholine is reduced in thiamine deficient rats produced by prolonged administration of tea. In those rats fed a normal diet and given tea (1:50, w/v) instead of drinking water for 20 weeks, the conversion of [14C] pyruvate to [14C]acetylcholine decreased by 35%. However, no neurological symptoms were observed. Administration of tea to rats fed a thiamine half-deficient diet for 7-8 weeks caused not only 60% decrease in acetylcholine synthesis but also neurological symptoms. This decreased synthesis of acetylcholine is related to a decline in pyruvate dehydrogenase activity. The results suggest that prolonged administration of tea to rats cause an impairment of acetyl CoA production resulting in a deficit in acetylcholine synthesizing capacity.
通过长期给予茶制备的硫胺素缺乏大鼠全脑乙酰胆碱的合成减少。在那些喂食正常饮食并给予茶（1:50，w/v）而非饮用水20周的大鼠中，[14C]丙酮酸向[14C]乙酰胆碱的转化降低了35%。然而，未观察到神经症状。给喂食硫胺素半缺乏饮食7 - 8周的大鼠给予茶，不仅使乙酰胆碱合成减少60%，还导致神经症状。乙酰胆碱合成的减少与丙酮酸脱氢酶活性的下降有关。结果表明，长期给大鼠给予茶会导致乙酰辅酶A生成受损，从而导致乙酰胆碱合成能力不足。
