Fehilly C B, Willadsen S M, Tucker E M
Nature. 1984;307(5952):634-6. doi: 10.1038/307634a0.
In rodents, chimaeric blastocysts produced by combining embryonic cells of two different species have been used in investigations of cell lineage and interaction during development (Mus musculus-Rattus norvegicus, M. musculus-Clethrionomys glareolus, M. musculus-Mus caroli). However, interspecific chimaerism also offers new approaches to the study of reproductive incompatibilities between species and may even allow such incompatibilities to be neutralized, thus improving the chances of successful hybridization and interspecific embryo transplantation. We report here the production of sheep-goat chimaeras by embryo manipulation and the use of interspecific chimaerism to allow successful interspecific embryo transplantation in sheep and goats.
在啮齿动物中，通过将两个不同物种的胚胎细胞结合产生的嵌合胚泡已被用于研究发育过程中的细胞谱系和相互作用（小家鼠-褐家鼠、小家鼠-棕背䶄、小家鼠-印度小鼠）。然而，种间嵌合现象也为研究物种间生殖不相容性提供了新方法，甚至可能使这种不相容性得到中和，从而提高成功杂交和种间胚胎移植的几率。我们在此报告通过胚胎操作产生绵羊-山羊嵌合体，以及利用种间嵌合现象实现绵羊和山羊种间胚胎移植的成功。
