Rousset S, Moscovici O, Lebon P, Barbet J P, Helardot P, Macé B, Bargy F, Chany C
Pediatrics. 1984 Feb;73(2):218-24.
Since the outbreaks of neonatal necrotizing enterocolitis occurring in maternity hospitals of Paris and suburbs in 1979-1980, it has been possible to examine by light and electron microscopy gut specimens from ten newborns with this illness. Coronavirus-like particles, enclosed in intracytoplasmic vesicles of damaged epithelial cells of the intestinal mucosa, were observed in the small intestine, appendix, and colon. The ultrastructural study, supported by bacteriologic findings, suggests the role of coronavirus-like particles in the appearance of the lesions. Secondary proliferation of mainly anaerobic bacteria, probably responsible for pneumatosis, may aggravate the disease.
自1979 - 1980年巴黎及其郊区的妇产医院爆发新生儿坏死性小肠结肠炎以来，现已能够通过光学显微镜和电子显微镜检查10例患有此病的新生儿的肠道标本。在小肠、阑尾和结肠中观察到，冠状病毒样颗粒包裹在肠黏膜受损上皮细胞的胞质内小泡中。这项超微结构研究得到细菌学检查结果的支持，提示冠状病毒样颗粒在病变形成过程中所起的作用。主要为厌氧菌的继发性增殖可能是导致肠壁积气的原因，这可能会加重病情。
