Igarashi T, Isaka S, Miyauchi T, Hayata I, Shimazaki J
Prostate. 1984;5(1):113-22. doi: 10.1002/pros.2990050111.
Establishment of a cell line derived from the androgen-independent subline of rat prostatic adenocarcinoma (Dunning R3327 tumor) is reported. Cells of this line produced acid phosphatase. When the cultured cells were transplanted to Copenhagen rats, solid tumors were formed. Histologically, the tumor consisted of spindle-shaped, large and bizarre polygonal cells; this feature was almost identical to that of the original tumor. Chromosomes were in the triploid range with seven frequently appearing marker chromosomes.
据报道，已建立了一种源自大鼠前列腺腺癌雄激素非依赖性亚系（邓宁R3327肿瘤）的细胞系。该细胞系的细胞产生酸性磷酸酶。将培养的细胞移植到哥本哈根大鼠体内时，会形成实体瘤。从组织学上看，肿瘤由梭形、大而怪异的多角形细胞组成；这一特征与原始肿瘤几乎相同。染色体处于三倍体范围内，有七条常见的标记染色体。
