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Conversion of 3-nitropropanol (miserotoxin aglycone) to 3-nitropropionic acid in cattle and sheep.

作者信息

Muir A D, Majak W, Pass M A, Yost G S

出版信息

Toxicol Lett. 1984 Feb;20(2):137-41. doi: 10.1016/0378-4274(84)90138-3.

DOI:10.1016/0378-4274(84)90138-3
PMID:6695404
Abstract

The metabolism of intravenously administered 3-nitropropanol (miserotoxin aglycone) was examined in cattle and sheep using high-pressure liquid chromatography (HPLC) to determine nitrocompounds in plasma. 3-Nitropropanol (NPOH) showed a rapid rate of decay and simultaneously, 3-nitropropionic acid (NPA) was detected at comparable levels in plasma. In animals dosed with NPOH, the observed NPA decayed at a slower rate than NPOH. Nitrite levels in plasma were more closely related to NPA than to NPOH. Therefore, metabolism of NPOH is linked to NPA and this could provide a common basis for the toxicity of these compounds in cattle and sheep.

摘要

相似文献

1
Conversion of 3-nitropropanol (miserotoxin aglycone) to 3-nitropropionic acid in cattle and sheep.
Toxicol Lett. 1984 Feb;20(2):137-41. doi: 10.1016/0378-4274(84)90138-3.
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