Pass M A, Majak W, Muir A D, Yost G S
Toxicol Lett. 1984 Oct;23(1):1-7. doi: 10.1016/0378-4274(84)90002-x.
When 3-nitropropanol (NPOH) was injected into the rumen (30 mg/kg), abomasum (10 mg/kg) or small intestine (10 mg/kg) of sheep, it was rapidly absorbed and converted to 3-nitropropionic acid (NPA). The reticulo-rumen was the major site of absorption for the miserotoxin aglycone but the abomasum and the small intestine also had the capacity to absorb NPOH. When NPA was injected into different regions of the alimentary tract, the reticulo-rumen was also the major site of absorption. Absorption of NPA or NPOH from the small intestine was much more rapid than from the abomasum. Plasma levels of NPA and inorganic nitrite were higher after dosing with NPOH than with NPA indicating a more rapid rate of uptake of the aglycone.
当将3-硝基丙醇（NPOH）注入绵羊的瘤胃（30毫克/千克）、皱胃（10毫克/千克）或小肠（10毫克/千克）时，它会迅速被吸收并转化为3-硝基丙酸（NPA）。瘤网胃是毒蝇碱苷元的主要吸收部位，但皱胃和小肠也有吸收NPOH的能力。当将NPA注入消化道的不同区域时，瘤网胃也是主要的吸收部位。NPA或NPOH从小肠的吸收比从皱胃快得多。用NPOH给药后血浆中NPA和无机亚硝酸盐的水平高于用NPA给药后的水平，这表明苷元的摄取速度更快。
