Miller T D, Cohen S M
Toxicol Lett. 1984 Feb;20(2):177-81. doi: 10.1016/0378-4274(84)90144-9.
Sodium saccharin has previously been demonstrated to induce hyperplasia of the urothelium of the rat kidney pelvis. It was fed as 5% of the diet to male F344 rats for 18 weeks. In the present experiment, scanning electron microscopy (SEM) was utilized to detect early morphologic changes. Pleomorphic microvilli (PMV) were observed in all four sodium saccharin-fed rats, located on cells at the junction of the papilla and pelvis. PMV also occurred at the papilla-pelvic junction in three of the ten control rats, but the affected area was smaller and the PMV exhibited less severe atypia.
先前已证明糖精钠可诱导大鼠肾盂尿路上皮增生。将其以饮食的5%喂给雄性F344大鼠18周。在本实验中，利用扫描电子显微镜（SEM）检测早期形态学变化。在所有四只喂食糖精钠的大鼠中，均观察到多形性微绒毛（PMV），位于乳头和肾盂交界处的细胞上。在十只对照大鼠中的三只的乳头-肾盂交界处也出现了PMV，但受影响的区域较小，且PMV表现出的异型性较轻。
