Mueller S M, Muller J, Asdell S M
Stroke. 1984 Jan-Feb;15(1):119-23. doi: 10.1161/01.str.15.1.119.
Phenylpropanolamine (PPA) is a drug that has been associated with serious side effects including stroke. It is often combined with caffeine in diet preparations and "look-alike" pills. In order to determine if PPA/caffeine can lead to stroke in normotensive and/or hypertensive rats, we administered the combination in six times the allowed human dose calculated on a per weight basis for the rats two times per day for five days. Subarachnoid and cerebral hemorrhage was noted in 18% of the hypertensive rats. A single PPA/caffeine administration (same dose) lead to acute hypertension in both the normotensive and hypertensive animals. These results suggest that PPA/caffeine can lead to cerebral hemorrhage in previously hypertensive animals when administered in greater than the allowed dosage. An acute elevation in blood pressure may be a contributing factor.
苯丙醇胺（PPA）是一种与包括中风在内的严重副作用相关的药物。它经常在减肥制剂和“仿冒”药丸中与咖啡因混合。为了确定PPA/咖啡因是否会导致正常血压和/或高血压大鼠中风，我们以大鼠体重计算，按照人类允许剂量的六倍，每天两次给药该混合物，持续五天。在18%的高血压大鼠中发现了蛛网膜下腔出血和脑出血。单次给予PPA/咖啡因（相同剂量）会导致正常血压和高血压动物出现急性高血压。这些结果表明，当以超过允许剂量给药时，PPA/咖啡因会导致先前高血压动物出现脑出血。血压的急性升高可能是一个促成因素。
