Iglesias J R, Richardson E P, Collia F, Santos A, Garcia M C, Redondo C
Acta Neuropathol. 1984;62(3):230-4. doi: 10.1007/BF00691857.
A case of an unusual congenital intramedullary tumor of the spinal cord is reported. A paraplegic 11-day-old boy with hypotonia and atrophy of the abdominal and lower-extremity muscles showed a complete myelographic block between T-5 and T-8. Surgical exploration disclosed an elongated tumor mass within the spinal cord, that blended with the surrounding nervous-system tissue. Light and electron microscopy showed that the tumor was composed of intermingled well differentiated astrocytes and fibroblasts. These two cell types often were surrounded by the same basal lamina. There were no intercellular junctions. Gliofibrils were abundant, and the interstitial spaces contained abundant collagen and reticulin fibers. There were no histological signs of malignancy. We conclude that this is a case of prenatally arising gliofibroma.
报告了一例不寻常的先天性脊髓髓内肿瘤病例。一名11天大的截瘫男婴，伴有肌张力减退以及腹部和下肢肌肉萎缩，脊髓造影显示T-5至T-8之间完全梗阻。手术探查发现脊髓内有一细长的肿瘤块，与周围神经系统组织融合。光镜和电镜检查显示，肿瘤由分化良好的星形胶质细胞和成纤维细胞混合组成。这两种细胞类型常被同一基底膜包绕。无细胞间连接。胶质原纤维丰富，间质内含有丰富的胶原纤维和网状纤维。无恶性组织学征象。我们得出结论，这是一例产前发生的胶质纤维瘤。
