Hammerman H, Alker K J, Schoen F J, Kloner R A
Am J Cardiol. 1984 Feb 1;53(4):604-7. doi: 10.1016/0002-9149(84)90038-9.
To determine whether piroxicam, a widely used, long-acting anti-inflammatory agent, causes scar thinning after acute myocardial infarction (MI), MI was produced in 16 anesthetized, open-chest dogs by ligation of the proximal left anterior descending coronary artery. The dogs were randomized into 2 groups and treated in a blinded fashion, 8 with piroxicam, 1 mg/kg i.v. at 15 minutes and at 3 hours after ligation (Group 1) and 8 with saline solution (Group 2). Two-dimensional echocardiograms were performed 7 days and 6 weeks after ligation. At 6 weeks, the dogs were killed and the hearts examined. Scar thickness was 7.1 +/- 0.3 mm in control dogs and 5.2 +/- 0.4 mm in piroxicam-treated dogs (p less than 0.01). The ratio of scar thickness to noninfarcted wall thickness was 0.87 +/- 0.03 (mean +/- standard error of the mean) in the control group, and was significantly lower (0.62 +/- 0.04) in the piroxicam-treated group (p less than 0.001). Regional function, expressed as the percent change in the area of the left ventricular cavity (% delta A) from short-axis 2-dimensional echocardiograms, was 42 +/- 3% 7 days after occlusion in the control group and was not significantly different in the treated group (34 +/- 5%). At the end of 6 weeks % delta A had improved in the piroxicam-treated group to 44 +/- 3% (p less than 0.05 compared with the value after 7 days), and was similar to % delta A of the control group at 6 weeks (43 +/- 3%). Thus, clinical doses of piroxicam administered early after MI caused moderate scar thinning, which was not associated with impairment of regional left ventricular function 6 weeks later.
为确定广泛使用的长效抗炎药吡罗昔康在急性心肌梗死（MI）后是否会导致瘢痕变薄，对16只麻醉开胸犬结扎左冠状动脉前降支近端制作MI模型。将犬随机分为2组并采用盲法治疗，8只给予吡罗昔康，结扎后15分钟及3小时静脉注射1mg/kg（第1组），8只给予生理盐水（第2组）。结扎后7天和6周进行二维超声心动图检查。6周时处死犬并检查心脏。对照组犬瘢痕厚度为7.1±0.3mm，吡罗昔康治疗组为5.2±0.4mm（p<0.01）。对照组瘢痕厚度与非梗死心肌壁厚度之比为0.87±0.03（均值±均值标准误），吡罗昔康治疗组显著降低（0.62±0.04）（p<0.001）。根据短轴二维超声心动图测得的左心室腔面积变化百分比（%ΔA）表示的局部功能，对照组闭塞后7天为42±3%，治疗组无显著差异（34±5%）。6周结束时，吡罗昔康治疗组%ΔA改善至44±3%（与7天后的值相比p<0.05），与对照组6周时的%ΔA（43±3%）相似。因此，MI后早期给予临床剂量的吡罗昔康会导致中度瘢痕变薄，且6周后与左心室局部功能损害无关。
