Ferrell R E, Hanis C L, Aguilar L, Tulloch B, Garcia C, Schull W J
Am J Epidemiol. 1984 Feb;119(2):159-66. doi: 10.1093/oxfordjournals.aje.a113734.
Total glycosylated hemoglobin was measured from capillary blood specimens obtained from a sample of 1880 individuals of Mexican-American ancestry residing in Starr County, Texas, between January 1981 and February 1982, as part of an epidemiologic survey to assess the prevalence of noninsulin-dependent diabetes mellitus (Type II). No significant difference was found between males and females. Diabetics were found to have significantly higher levels of glycosylated hemoglobin than nondiabetics. However, among diabetics, there was no significant difference between newly diagnosed and known diabetics, and known diabetics taking medication did not differ significantly from those not taking medication. An analysis of the specificity and sensitivity of glycosylated hemoglobin, fasting blood glucose, and casual blood glucose determinations as screening devices in a survey of diabetes prevalence reveals that glycosylated hemoglobin is superior to casual blood glucose determination. The conditions under which various screening devices might be more effective are discussed.
1981年1月至1982年2月期间，作为一项评估非胰岛素依赖型糖尿病（II型）患病率的流行病学调查的一部分，对居住在得克萨斯州斯塔尔县的1880名墨西哥裔美国人的毛细血管血标本进行了总糖化血红蛋白测量。未发现男性和女性之间存在显著差异。发现糖尿病患者的糖化血红蛋白水平明显高于非糖尿病患者。然而，在糖尿病患者中，新诊断的糖尿病患者和已知糖尿病患者之间没有显著差异，并且正在服药的已知糖尿病患者与未服药的患者之间也没有显著差异。对糖化血红蛋白、空腹血糖和随机血糖测定作为糖尿病患病率调查筛查手段的特异性和敏感性分析表明，糖化血红蛋白优于随机血糖测定。讨论了各种筛查手段可能更有效的条件。
