Fox H, Herd M E, Harilal K R
Histopathology. 1978 Mar;2(2):145-51. doi: 10.1111/j.1365-2559.1978.tb01702.x.
Seventeen placentae from second trimester abortions induced by the injection of extra-amniotic prostaglandin have been examined. The extraplacental membranes, the chorionic plate of the placenta, the placental intervillous space and the placental villi were normal in all cases. In all but one specimen lesions were, however, noted in the decidua, these including focal decidual necrosis, intradecidual haemorrhage, thrombosis of maternal vessels and dilatation and congestion of the maternal vasculature. Similar decidual lesions were also seen in placentae from spontaneous and surgical second trimester abortions and it is concluded that prostaglandins do not produce any specific lesions in the placenta or decidua. It is suggested that the negative findings of this study indicate that prostaglandins do not induce abortion by either direct injury to the placenta or by provoking utero-placental ischaemia.
对17例因羊膜外注射前列腺素引产的中期妊娠胎盘进行了检查。所有病例的胎盘外膜、胎盘绒毛膜板、胎盘绒毛间隙和胎盘绒毛均正常。然而，除1个标本外，其余所有标本的蜕膜均有病变，包括局灶性蜕膜坏死、蜕膜内出血、母体血管血栓形成以及母体血管系统扩张和充血。在自然流产和手术流产的中期妊娠胎盘中也可见类似的蜕膜病变，得出的结论是，前列腺素不会在胎盘或蜕膜中产生任何特异性病变。本研究的阴性结果表明，前列腺素不会通过直接损伤胎盘或引起子宫胎盘缺血来诱导流产。
