Gutierrez Y, Maksem J A, Reiner N E
Am J Pathol. 1984 Feb;114(2):222-30.
The histopathologic changes in liver, spleen, and bone marrow of BALB/c mice infected for 6 months with Leishmania donovani are described. Granulomas were the most important histologic lesions found; and the dynamics of their formation, collagen deposition, and resolution in the liver were studied. The number of hepatic granulomas increased until the eighth week and then decreased steadily. In contrast to the liver granulomas, those of spleen and bone marrow do not mature or show collagen deposition. Actual granuloma counts in the liver support the idea that mature granulomas revert to poorly formed ones and finally resolve without scarring. BALB/c mice are suitable for the study of the dynamics of granuloma formation and resolution and the survival of L donovani in an in vivo system. The relevance of these changes to the pathology of L donovani infection in man are discussed.
描述了感染杜氏利什曼原虫6个月的BALB/c小鼠肝脏、脾脏和骨髓的组织病理学变化。肉芽肿是发现的最重要的组织学病变；研究了其在肝脏中的形成、胶原沉积和消退动态。肝脏肉芽肿数量在第8周前增加，然后稳定下降。与肝脏肉芽肿不同，脾脏和骨髓的肉芽肿不成熟或无胶原沉积。肝脏中实际肉芽肿计数支持成熟肉芽肿会恢复为形成不良的肉芽肿并最终无瘢痕消退的观点。BALB/c小鼠适用于研究肉芽肿形成和消退动态以及杜氏利什曼原虫在体内系统中的存活情况。讨论了这些变化与人类杜氏利什曼原虫感染病理学的相关性。
