Bromley M, Fisher W D, Woolley D E
Ann Rheum Dis. 1984 Feb;43(1):76-9. doi: 10.1136/ard.43.1.76.
Cartilage-pannus junctions of the rheumatoid lesion have been examined by histochemical and ultrastructural techniques in an attempt to identify the cells responsible for cartilage degradation. Mast cells have been identified at sites of cartilage erosion in 3 specimens of rheumatoid joint. It is known that mast cells participate in immunological reactions, produce the vasoactive and proteinase-modulating agents histamine and heparin as well as their own degradative proteinases. The close association of mast cells with sites of cartilage erosion suggests they may play an important role in the pathophysiology of joint destruction in rheumatoid arthritis.
通过组织化学和超微结构技术对类风湿性病变的软骨-血管翳交界处进行了检查，以确定负责软骨降解的细胞。在3例类风湿性关节标本的软骨侵蚀部位发现了肥大细胞。已知肥大细胞参与免疫反应，产生血管活性和蛋白酶调节因子组胺和肝素以及它们自身的降解蛋白酶。肥大细胞与软骨侵蚀部位的密切关联表明它们可能在类风湿性关节炎关节破坏的病理生理学中起重要作用。
