Permin H, Skov P S, Norn S, Geisler A, Klysner R, Andersen V, Wiik A, Manthorpe R, Nielsen H, Petersen J
Allergy. 1981 Aug;36(6):435-6. doi: 10.1111/j.1398-9995.1981.tb01852.x.
Basophilocytes from patients with rheumatoid arthritis (RA) responded to leukocyte nuclei from normal persons with histamine release; a similar histamine release induced by the nuclear components RNA and DNA has been demonstrated previously. A role of histamine in RA is also supported by the findings of clinical improvement during treatment with H1 and H2 antihistamines in six of 12 patients with RA in active phase, whereas four showed definite deterioration.
类风湿关节炎（RA）患者的嗜碱性粒细胞对正常人的白细胞核有组胺释放反应；此前已证明核成分RNA和DNA也可诱导类似的组胺释放。12例处于活动期的RA患者中，6例在使用H1和H2抗组胺药治疗期间临床症状改善，而4例则明显恶化，这一发现也支持了组胺在RA中的作用。
