Sheikh K M, Duggal K, Relfson M, Gignac S, Rowden G
Arch Surg. 1984 Feb;119(2):215-9. doi: 10.1001/archsurg.1984.01390140071012.
Tissue reactions to surgical glove powders, ie, talc (magnesium silicate) and Keoflo (low cross-linked cornstarch) were studied histologically from day 1 to 16 weeks. These materials were tested as a contaminant on the surface of surgical suture or in a pellet form implanted in abdominal muscle of rat. Use of Keoflo resulted in an intense acute inflammatory response, with a progressive decrease in the amount of starch with time after implant. By the fourth week, most of the starch had disappeared with minimal tissue damage and scar formation. Rats implanted with talc showed an initial mild to moderate acute inflammation followed by chronic inflammatory response and granuloma formation by the third day. From the fourth week on, granulomas showed talc crystals within the giant cells surrounded by histiocytes, lymphocytes, some collagen, and fibroblasts. This study indicates that talc molecules are not absorbed, whereas low cross-linked cornstarch is an absorbable substance; therefore the latter is a safe material for use as surgical glove powder.
从第1天到16周，对手术手套粉末（即滑石粉（硅酸镁）和Keoflo（低交联玉米淀粉））的组织反应进行了组织学研究。这些材料作为污染物在手术缝线表面进行测试，或以颗粒形式植入大鼠腹部肌肉中。使用Keoflo会引发强烈的急性炎症反应，植入后随着时间推移淀粉量逐渐减少。到第四周时，大部分淀粉已消失，组织损伤和瘢痕形成最小。植入滑石粉的大鼠最初表现为轻度至中度急性炎症，随后在第三天出现慢性炎症反应和肉芽肿形成。从第四周开始，肉芽肿在巨细胞内可见滑石晶体，周围有组织细胞、淋巴细胞、一些胶原蛋白和成纤维细胞。这项研究表明，滑石分子不会被吸收，而低交联玉米淀粉是一种可吸收物质；因此，后者是用作手术手套粉末的安全材料。
