Murray E A, Mishkin M
Behav Brain Res. 1984 Jan;11(1):67-83. doi: 10.1016/0166-4328(84)90009-3.
Rhesus monkeys with ablations of either the second somatosensory cortex (SII) or of the superior parietal lobule (area 5) were tested on a battery of tactile discrimination tasks in order to help determine which of these areas might constitute part of a postulated cortico-limbic tactile processing pathway. Monkeys with ablations of SII were severely impaired on both texture and shape discrimination learning and had markedly elevated size and roughness discrimination thresholds relative to control animals. By contrast, monkeys with area 5 lesions were impaired only on roughness thresholds, and these were elevated only moderately. Although more severe tactile deficits following lesions of area 5 have been reported previously, they were found in the present study only when the area 5 removals were extended slightly rostrally, in a third operated group, to include the posteromedial part of the hand representation of area 2. These results are consistent with the suggestion that SII, but not area 5, is a critical station in a tactile processing pathway that proceeds from the primary somatosensory cortex (SI) to the limbic structures of the temporal lobe through links in SII and the insular cortex.
对切除了第二体感皮层（SII）或顶上小叶（5区）的恒河猴进行了一系列触觉辨别任务测试，以帮助确定这些区域中的哪一个可能构成假定的皮质 - 边缘触觉处理通路的一部分。切除SII的猴子在纹理和形状辨别学习方面严重受损，并且相对于对照动物，其大小和粗糙度辨别阈值明显升高。相比之下，5区损伤的猴子仅在粗糙度阈值上受损，并且仅适度升高。尽管先前曾报道过5区损伤后更严重的触觉缺陷，但在本研究中，仅在第三个手术组中，当5区切除范围稍微向头侧扩展以包括2区手部代表的后内侧部分时才发现这些缺陷。这些结果与以下观点一致，即SII而非5区是触觉处理通路中的关键站点，该通路从初级体感皮层（SI）通过SII和岛叶皮层中的连接通向颞叶的边缘结构。
