日光性荨麻疹临床耐受性机制的研究。

Studies on the mechanism of clinical tolerance in solar urticaria.

作者信息

Keahey T M, Lavker R M, Kaidbey K H, Atkins P C, Zweiman B

出版信息

Br J Dermatol. 1984 Mar;110(3):327-38. doi: 10.1111/j.1365-2133.1984.tb04639.x.

DOI:10.1111/j.1365-2133.1984.tb04639.x

Abstract

Tolerance to artificial ultraviolet radiation (UVR) was induced in three patients with solar urticaria by administering graded whole body exposures to long-wave ultraviolet radiation (UV-A, 320-400 nm) in a phototherapy cabinet. Plasma histamine levels, mast cell ultrastructure and cutaneous responses to intradermally injected codeine and histamine were examined before and after the induction of tolerance. No evidence of serum complement activation could be demonstrated following exposure of serum samples to UVR in vitro. These studies suggest that the state of tolerance is due neither to mediator (histamine) depletion nor to a systemic effect induced by UV-A but may be due to an increase in the mast cell degranulation threshold.

摘要

通过在光疗箱中对三名日光性荨麻疹患者进行分级全身长波紫外线辐射（UV-A，320 - 400纳米）照射，诱导其对人工紫外线辐射（UVR）产生耐受性。在诱导耐受性前后，检测了血浆组胺水平、肥大细胞超微结构以及对皮内注射可待因和组胺的皮肤反应。在体外将血清样本暴露于UVR后，未发现血清补体激活的证据。这些研究表明，耐受状态既不是由于介质（组胺）耗竭，也不是由于UV-A诱导的全身效应，而可能是由于肥大细胞脱颗粒阈值升高所致。