Hawk J L, Eady R A, Challoner A V, Kobza-Black A, Keahey T M, Greaves M W
Br J Clin Pharmacol. 1980 Feb;9(2):183-6. doi: 10.1111/j.1365-2125.1980.tb05831.x.
1 Ultraviolet radiation (UVR)-induced wealing was studied in four patients with solar urticaria, whose measured action spectra were within the range 300 to 700 nm. 2 Elevated histamine levels were found in blood draining wealed skin in all four patients. 3 Histological and electron microscopial studies of the irradiated skin showed evidence of mast cell degranulation. 4 These findings demonstrate an association between histamine release from mast cells and wealing in solar urticaria, and should encourage evaluation of drugs which suppress histamine release in this disorder.
