Buckley N M, Brazeau P, Charney A N, Cabili S, Feldman G, Garvey M, Frasier I D
Biol Neonate. 1984;45(2):69-77. doi: 10.1159/000241779.
The cardiovascular and renal effects of intravenous (i.v.) and intra-arterial (i.a.) infusions of isoproterenol (ISP, 0.1-0.2 micrograms/kg/min) were evaluated in 17 two-week-old swine anesthetized with pentobarbital. The glomerular filtration rate (GFR) of each kidney and blood flow and vascular resistance (RVR) of the left kidney were determined in all animals. In the 8 animals given ISP i.v., right ventricular pressure and dP/dtmax were also determined via a thoracotomy. In 9 animals, ISP was given i.a. after stabilization of constant-flow perfusion of the left kidney in situ. During i.v. infusion of ISP, the positive inotropic and chronotropic effects and the decrease in arterial pressure were maintained; renal blood flow and GFR increased and RVR decreased. During i.a. infusion of ISP in the constant-flow perfused kidney, similar changes in RVR and GFR were observed despite the higher effective concentrations of drug reaching the kidney. We conclude that, at this stage of postnatal renal development, the infusion of cardiotonic doses of ISP lowers RVR and produces a small increase in GFR.
在17只接受戊巴比妥麻醉的两周龄猪中，评估了静脉注射（i.v.）和动脉内注射（i.a.）异丙肾上腺素（ISP，0.1 - 0.2微克/千克/分钟）对心血管和肾脏的影响。测定了所有动物每个肾脏的肾小球滤过率（GFR）以及左肾的血流量和血管阻力（RVR）。在8只静脉注射ISP的动物中，还通过开胸手术测定了右心室压力和dP/dtmax。在9只动物中，在左肾原位恒流灌注稳定后进行动脉内注射ISP。在静脉注射ISP期间，正性肌力和变时性作用以及动脉压降低得以维持；肾血流量和GFR增加，RVR降低。在恒流灌注肾脏中动脉内注射ISP期间，尽管到达肾脏的药物有效浓度较高，但仍观察到RVR和GFR有类似变化。我们得出结论，在出生后肾脏发育的这个阶段，输注强心剂量的ISP会降低RVR并使GFR略有增加。
