Emens M
Br J Hosp Med. 1984 Jan;31(1):42-8.
Unlike the effects of Thalidomide on the developing child, those of DES are not readily apparent at birth. The administration of DES and its sequelae are in this respect a unique medical experience. Fortunately, with the realization that late sequelae occur, the use of the drug in pregnancy has been discontinued and the problems are likely to be self-limiting. The link between DES and particularly the benign changes in the vagina and cervix (adenosis) seems well established. The association between this drug and the development of genital malignancies is less clear, and the very low incidence in the prospective studies in the USA supports this concept. The size of the problem in the UK is small, but clinicians should be aware that it exists. Cases of vaginal adenosis in young women should be investigated and screened appropriately, and preferably referred to centres where colposcopic expertise is available. Treatment of simple vaginal adenosis should be avoided.
与沙利度胺对发育中胎儿的影响不同，己烯雌酚的影响在出生时并不明显。己烯雌酚的使用及其后遗症在这方面是一种独特的医学经历。幸运的是，随着人们认识到会出现晚期后遗症，孕期已停止使用该药物，问题可能会自行得到控制。己烯雌酚与尤其是阴道和宫颈的良性变化（腺病）之间的联系似乎已得到充分证实。这种药物与生殖器恶性肿瘤发生之间的关联尚不清楚，美国前瞻性研究中的极低发病率支持了这一观点。在英国，这个问题的规模较小，但临床医生应意识到它的存在。年轻女性的阴道腺病病例应进行适当的调查和筛查，最好转诊至具备阴道镜专业知识的中心。应避免对单纯性阴道腺病进行治疗。
