十种非甾体抗炎药镇痛效果的比较

Comparison of the analgesic effect of ten nonsteroidal anti-inflammatory drugs.

作者信息

Isomäki H, Martio J, Kaarela K, Kajander A, Koota K, Lehtinen K, Luukkainen R, Martio T, Nissilä M, Nuotio P

出版信息

Br J Rheumatol. 1984 Feb;23(1):61-5. doi: 10.1093/rheumatology/23.1.61.

DOI:10.1093/rheumatology/23.1.61

Abstract

The analgesic effect of 10 anti-inflammatory drugs was compared using a single-blind method in 90 patients with rheumatoid arthritis. Each patient received two different drugs, for three days each and each drug was evaluated in 18 patients. After the trial, the patients considered which of the drugs they preferred. The greatest relief from pain was achieved by diclofenac, indomethacin, naproxen and tolfenamic acid, each of these being preferred by the majority of patients and being significantly (p less than 0.01) better than the least effective drugs ketoprofen and proquazone. Acetylsalicylic acid, azapropazone, carprofen and ibuprofen were considered intermediate in efficacy.

摘要

采用单盲法对90例类风湿性关节炎患者使用10种抗炎药的镇痛效果进行了比较。每位患者接受两种不同药物，每种药物服用三天，每种药物在18例患者中进行评估。试验结束后，让患者考虑他们更喜欢哪种药物。双氯芬酸、吲哚美辛、萘普生和托芬那酸止痛效果最佳，大多数患者更喜欢这些药物，且它们明显（p<0.01）优于效果最差的药物酮洛芬和丙氧苯唑。乙酰水杨酸、阿扎丙宗、卡洛芬和布洛芬的疗效被认为处于中等水平。